The Role of Carbohydrates in Transplantation

Grant number: 566722 | Funding period: 2009 - 2011

Completed

Abstract

Xenotransplantation, the transplanting of organs from other species, is now seen as a viable solution to the problem of lack of supply of suitable human donors. The recent production of genetically engineered pigs represented a critical step towards clinical xenotransplantation. However, other sugars still remain that cause rejection. This project examines the consequences of these sugars.

Related publications (5)

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Structural glycobiology of antibody recognition in xenotransplantation and cancer immunotherapy

M Agostino, W Farrugia, MS Sandrin, AM Scott, E Yuriev, PA Ramsland

2014-10-01

Carbohydrate antigens recognized by natural or preformed and elicited antibodies are central to transplantation/transfusion reject..

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Challenges and advances in computational docking: 2009 in review

E Yuriev, M Agostino, PA Ramsland

2011-03-01

Docking is a computational technique that places a small molecule (ligand) in the binding site of its macromolecular target (recep..

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Peptide inhibitors of xenoreactive antibodies mimic the interaction profile of the native carbohydrate antigens

M Agostino, MS Sandrin, PE Thompson, PA Ramsland, E Yuriev

2011-01-01

Carbohydrate-antibody interactions mediate many cellular processes and immune responses. Carbohydrates expressed on the surface of..

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Identification of preferred carbohydrate binding modes in xenoreactive antibodies by combining conformational filters and binding site maps

M Agostino, MS Sandrin, PE Thompson, E Yuriev, PA Ramsland

2010-02-22

Carbohydrates are notoriously flexible molecules. However, they have an important role in many biochemical processes as specific l..

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In silico analysis of antibody-carbohydrate interactions and its application to xenoreactive antibodies

M Agostino, MS Sandrin, PE Thompson, E Yuriev, PA Ramsland

2009-12-01

Antibody-carbohydrate interactions play central roles in stimulating adverse immune reactions. The most familiar example of such a..

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